Serenity Wheeler (voiced by Lisa Ortiz) is Joey Wheeler's little sister. Ever since she was a child, Serenity has had problems with her eyes. Soon she would have gone blind. But thanks to Joey who won the prize money at Duelist Kingdom, he was able to afford the operation to have her eyes fixed. She doesn't really duel that much, and likes to spend time with her friends, including Téa. When she does duel, she mainly uses fairies, with her ace being Saint Joan. She is very kind, and caring, especially to Joey.
- When Joey marries Mai, Serenity becomes Mai's sister-in-law.
- Serenity will first appear in The Next King of Games.
- Serenity will guest star in Jeffrey, Jaden & Friends' Storm Adventures of The 7D.
- In Japan, Serenity is Shizuka Kawai.