Megamind (voiced by Will Ferrell) is the main protagonist of Jaden meets Megamind. Jaden and King Julien made a bet that if Jaden could redeem another villain, Julien would have to treat Mort more nicely. But if he couldn't, Jaden would have to celebrate King Julien Day for a week. Jaden chose to redeem Megamind, by becoming his minions, and slowly working their way into his heart.
Megamind is the arch enemy of Metro Man, hero of Metro City. After destroying Metro Man, Megamind took over the city, but became tired of doing evil things. So he created a new hero named Tighten to have someone to fight. While he trained him to be like Metro Man, Megamind was falling in love with Roxanne Ritchi, and was slowly becoming more good than evil. But after Tighten turned evil, Megamind stopped him, and he became the new hero of Metro City.