Isis is Osiris' wife and sister, and is the goddess of Magic and Light. In Egyptian mythology, when Osiris was killed by his evil brother Set, Isis found Osiris and brought him to life so that she could conceive their son Horus.
- Just as Jaden serves under Osiris, Jaden also has Isis as another one of his bosses. After Jeffrey meets her, Isis will become one of his bosses.
- While Osiris brought Xion back to life, Isis was the one who created Xion's very own heart. To do this, she took the DNA from two people, Jeffrey and Aqua, and with her magic was able to create a heart completely devoid of darkness.
- Isis will attend Jesse and May's wedding in Rainbow Bond.
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